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英文名稱 Anti-Glutaredoxin 2
中文名稱 谷氧還蛋白2抗體
別 名 bA101E13.1 （GRX2 glutaredoxin （thioltransferase） 2）; bA101E13.1; CGI133; Glrx2; GLRX2_HUMAN; Glutaredoxin-2; Glutaredoxin-2, mitochondrial; GRX2; mitochondrial.
濃 度 1mg/1ml
規(guī) 格 0.2ml/200μg
抗體來源 Rabbit
克隆類型 polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep
產(chǎn)品類型 一抗
研究領(lǐng)域 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 新陳代謝 表觀遺傳學(xué)
46748FSH-R（Follicle-stimulating hormone receptor precursor） 促卵泡刺激素受體抗原 0.5mg
46749FSH（Follicle-stimulating hormone precursor） 促卵泡刺激素抗原 0.5mg
46750GABRA1（gamma-aminobutyric acid （GABA） A receptor, alpha 1） γ1氨基丁酸A型受體α1抗原 0.5mg
46751GABAB1（GABAb Receptor 1） g-氨基丁酸B1受體（多肽） 0.5mg
46752GABABR2/GB2（GABA B Receptor 2） γ1氨基丁酸A型受體B2抗原 0.5mg
46753GAD-67 （glutamate decarboxylase 67） 谷氨酸脫羧酶-67抗原 0.5mg
46754GADD153（Growth arrest and DNA damage-inducible 153） 生長(zhǎng)抑制DNA損傷基因153抗原 0.5mg
46755phospho GAP-43（pSer41）（phospho Growth associated protein 43 ） 磷酸化神經(jīng)生長(zhǎng)相關(guān)蛋白43抗原 0.5mg
46756GAPDH 3-磷酸甘油醛脫氫酶（人）抗原 0.5mg
46757CXCR3/CD183 peptide 細(xì)胞表面趨化因子受體3抗原 0.5mg
46758GATA-3（GATA binding factor 3） GATA結(jié)合蛋白3抗原 0.5mg
46759GATA-4（GATA binding factor 4） GATA結(jié)合蛋白4抗原 0.5mg
46760Gax（growth arrest-specific homeobox） 生長(zhǎng)終止特異性同源盒基因抗原 0.5mg
46761GDF8/MSTN（growth differntiation factor 8） 生長(zhǎng)分化因子8抗原 0.5mg
46762GDNF （Glial cell line-derived neurotrphic factor） 膠質(zhì)細(xì)胞源性神經(jīng)營養(yǎng)因子抗原 0.5mg
46763Gelsolin 凝溶膠蛋白抗原 0.5mg
46764GFP 綠色熒光蛋白 0.5mg
46765GFP 綠色熒光蛋白 0.5mg
46766GITR （glucocorticoidinduced tumor necrosis factor receptor） 糖皮質(zhì)激素誘導(dǎo)腫瘤壞死因子受體抗原 0.5mg
46767GLI1（GLI-Kruppel family member 1） 下游轉(zhuǎn)錄因子Gli1蛋白抗原 0.5mg
46768GLP-1/KG-31（Glucagon-like peptide-1） peptide 胰高血糖素樣肽-1（多肽） 0.5mg
46769GLP-1 peptide 胰高血糖素樣肽-1（多肽） 0.1mg
46770GLP-1R peptide 胰高血糖素樣肽-1受體多肽 0.5mg
46771GLUT3（Glucose transporter 3） 葡萄糖轉(zhuǎn)運(yùn)蛋白3抗原 0.5mg
46772GM-CSF（Granulocyte-Macrophage Colony Stimulating Factors） 粒細(xì)胞-巨噬細(xì)胞克隆刺激因子抗原 0.5mg
蛋白分子量 predicted molecular weight: 16kDa
性 狀 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human Glutaredoxin 2
亞 型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione （GSH）, but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
Function : Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione （GSH）, but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
Subunit : Monomer; active form. Homodimer; inactive form. The homodimer is probably linked by 1 2Fe-2S cluster.
Subcellular Location : Mitochondrion and Nucleus.
Tissue Specificity : Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes.
Similarity : Belongs to the glutaredoxin family.
Contains 1 glutaredoxin domain.
Database links : UniProtKB/Swiss-Prot: Q9NS18.1