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【公司名稱】 廣州健侖生物科技有限公司
【】 楊永漢
【】
【騰訊 】 2042552662
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-3室
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博士生劉巧珍等利用轉(zhuǎn)基因小鼠特異性標(biāo)記追蹤心外膜細(xì)胞發(fā)育的命運(yùn)。結(jié)果發(fā)現(xiàn),胚胎期標(biāo)記的心外膜細(xì)胞除了分化成冠狀血管平滑肌細(xì)胞外,還可形成心臟房室之間的脂肪細(xì)胞。但在成體中再度標(biāo)記心外膜時(shí)卻觀察不到,這表明成體穩(wěn)態(tài)中心外膜轉(zhuǎn)變成脂肪的能力被抑制。研究證明成體心臟損傷時(shí),心外膜細(xì)胞可再度激發(fā)胚胎發(fā)育中的一些特性,分化成其他類型細(xì)胞。
該工作進(jìn)一步研究了心臟損傷情況下心外膜細(xì)胞轉(zhuǎn)變成脂肪細(xì)胞的能力,并意外發(fā)現(xiàn)損傷部位形成脂肪組織,而其中部分脂肪細(xì)胞正是來源于心外膜。研究還發(fā)現(xiàn),心外膜及其衍生的細(xì)胞是具有多能性的,在不同的培養(yǎng)條件下可被誘導(dǎo)成脂肪細(xì)胞、軟骨細(xì)胞和成骨細(xì)胞。
日本岡山大學(xué)醫(yī)院日前宣布,其研究人員在人體血液中發(fā)現(xiàn)了一種能夠遏制癌細(xì)胞增殖并消滅癌細(xì)胞的抗體。這一發(fā)現(xiàn)將有助開發(fā)出副作用較小的化療藥物。
健康人的體內(nèi)每天都會(huì)出現(xiàn)數(shù)千個(gè)癌細(xì)胞,但是被各種抗體和免疫細(xì)胞清理掉了,科學(xué)家并不清楚其中的機(jī)制。
該院研究人員注意到,在癌細(xì)胞中,核糖體蛋白L29得以高度表達(dá),而人體血液中就存在核糖體蛋白L29的抗體。
研究人員將每毫升中含有5微克(1微克是百萬分之一克)抗體的溶液滴到人類肝癌細(xì)胞上,再調(diào)查癌細(xì)胞的增殖狀況。結(jié)果發(fā)現(xiàn),癌細(xì)胞的增殖減少40%。
Ph.D student Liu Qiaozhen and other transgenic mice using specific markers to track the fate of epicardial cell development. The results showed that embryonic epicardial cells in addition to differentiate into coronary vascular smooth muscle cells, but also the formation of fat cells between the heart chamber. But was not observed when the epicardium was re-labeled in adults, suggesting that the ability of the adult, steady-state central epicardium to transform into fat is inhibited. Studies have shown that adult heart injury, epicardial cells can once again stimulate some of the characteristics of embryonic development, differentiation into other types of cells.
This work further explores the ability of epicardial cells to translocate into adipocytes under cardiac injury and unexpectedly finds adipose tissue at the site of injury, some of which are derived from the epicardium. The study also found that the epicardium and its derived cells are pluripotent and can be induced into adipocytes, chondrocytes and osteoblasts under different culture conditions.
Japan's Okayama University Hospital recently announced that its researchers found in human blood a can curb cancer cell proliferation and eliminate cancer cells antibodies. This discovery will help to develop chemotherapy drugs with less side effects.
Thousands of cancer cells appear in a healthy human body daily, but are cleared by various antibodies and immune cells, and scientists are not clear about the mechanism.
Researchers at the hospital noticed that the ribosomal protein L29 is highly expressed in cancer cells, while the human blood contains antibodies to the ribosomal protein L29.
Researchers drip a solution containing 5 micrograms (1 microgram per million) of antibody per milliliter onto human liver cancer cells and investigate the proliferation of cancer cells. The results showed that the proliferation of cancer cells decreased by 40%.