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當前位置：深圳欣博盛生物科技有限公司>>抗體>>內(nèi)參抗體>> InVivoMAb anti-mouse FGL-1
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品 牌BioxCell
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所 在 地深圳市
更新時間：2022-01-27 11:18:30瀏覽次數(shù)：631次
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InVivoMab anti-human CD25 (IL-2Rα)
| 供貨周期 | 一個月 | 規(guī)格 | 5mg |
|---|---|---|---|
| 貨號 | BE0332-5MG | 應(yīng)用領(lǐng)域 | 生物產(chǎn)業(yè) |
| 主要用途 | 科研 |
The 177R4 monoclonal antibody reacts with mouse Fibrinogen-like protein 1 (FGL-1). FGL-1 is a member of the fibrinogen family of proteins. Under normal physiological conditions, FGL-1 is primarily secreted from hepatocytes and contributes to mitogenic and metabolic functions. FGL-1 is produced at high levels in various tumors including lung cancer and melanoma. High FGL-1 expression is associated with resistance to anti-PD-1/PD-L1 therapy and poor prognosis of cancer patients. Recently, FGL-1 has been identified as a major inhibitory ligand for LAG-3, a receptor that negatively regulates the proliferation, activation, and effector function of T cells. In murine cancer models, the 177R4 clone has been shown to block FGL-1 binding to LAG-3 resulting in boosted T cell activity and slowed tumor growth.
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