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Prednisone

CAS No. : 53-03-2

MCE 國際站：Prednisone

產(chǎn)品活性：Prednisone (Adasone) 是皮質(zhì)類固醇試劑，具有抗炎及免疫抑制作用，可用于研究系統(tǒng)性紅斑狼瘡等相關(guān)疾病。

研究領(lǐng)域：Immunology/Inflammation  |  Vitamin D Related/Nuclear Receptor  |  Apoptosis

作用靶點(diǎn)：Glucocorticoid Receptor  |  Apoptosis

In Vivo: Prednisone (intramuscular injection, 10 mg/kg once a day, on days 4 to 13) reduces the survival rate on days lower than the control group in BALB/c mice with encephalomyocarditis virus myocarditis. Besides, myocardial virus titers reaches a maximum on day 4, but there is no antibody titer, and on day 8 virus titers remains elevated and antibody titers is also high. On day 10, antibody titers are significantly lower than controls, while viral titers remains significantly elevated.
Prednisone (5 mg/kg, intragastrically administration, daily) can cause changes in FA metabolism in SLE mouse (MRL/lpr) model.

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