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GIPR/CRE Luciferase Reporter HEK293 Cell Line is an engineered HEK293 cell line expressing firefly luciferase under the control of cAMP response element (CRE), and human GIPR (Gastric Inhibitory Polypeptide receptor; NM_000164.4). Activation of GIPR in these cells can be monitored by measuring luciferase activity.
The functionality of the GIPR/CRE Luciferase Reporter HEK293 Cell Line was validated in dose-response assays using the agonists gastric inhibitory peptide (GIP), Tirzepatide, and Retatrutide. These agonists induce luciferase activity in a dose-dependent manner as depicted in Figure 1.
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Figure 1. Illustration of the mechanism of action in the GIPR/CRE Luciferase Reporter HEK293 Cell Line.
Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.
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