Epigentek 創(chuàng)新技術(shù)和表觀遺傳學
Epigentek集團公司是全球創(chuàng)新技術(shù)和表觀遺傳學相關(guān)研究產(chǎn)品的開發(fā)商和供應商。公司開發(fā)了包括400多個產(chǎn)品的全面的產(chǎn)品組合，為表觀遺傳學方面的研究和新藥研發(fā)提供全面系統(tǒng)的解決方案。2019年，Epigentek榮獲“Bioz Rising Star TM ",被評為2019表觀遺傳學領(lǐng)域的新星公司。
Epigentek公司的產(chǎn)品銷售領(lǐng)域
全shi界的備受推崇的學者、制藥企業(yè)以及很多專業(yè)的生物技術(shù)公司都在使用Epigentek產(chǎn)品。相比普通方法的產(chǎn)品而言，這些du特的產(chǎn)品在科研分析過程中更簡單、更快捷、更方便、更有效。Epigentek公司的產(chǎn)品通過專門的銷售隊伍和遍布全球超過36個國家和地區(qū)的經(jīng)銷商進行銷售。讓客戶滿意和幫助客戶在試驗中取得最大成功是我們進行技術(shù)創(chuàng)新的首要任務。公司特別強調(diào)技術(shù)的速度和效率，繼續(xù)側(cè)重于表觀遺傳學創(chuàng)新和廣泛發(fā)展，提高其產(chǎn)品組合。
Epigentek公司的產(chǎn)品類型
專業(yè)提供DNA甲基化試劑盒、組蛋白修飾相關(guān)試劑盒、染色質(zhì)免疫沉淀反應試劑盒、基因表達與沉默檢測試劑盒、DNA損傷及修復試劑盒、SUMO化修飾分析試劑盒、表型相關(guān)抗體等表觀遺傳學產(chǎn)品。
蛋白質(zhì)與DNA之間的動態(tài)相互作用，參與并推動了基因的表達、調(diào)控、復制、重組和修復以及RNA的轉(zhuǎn)運、翻譯和調(diào)控等多個生物學過程，幾乎涉及所有的生命活動。繪制這些蛋白質(zhì)-DNA結(jié)合事件發(fā)生的時空關(guān)系，對于正常發(fā)育和疾病中表觀遺傳學的機理研究至關(guān)重要。
為了生成這種數(shù)據(jù)，科學家通常使用ChIP（染色質(zhì)免疫沉淀）-Seq法。傳統(tǒng)的ChIP-Seq實驗需要花費三天來完成：首先進行染色質(zhì)交聯(lián)（使用甲醛作為交聯(lián)劑），使基因組上分布的蛋白以及各種修飾定格下來，然后對交聯(lián)的染色質(zhì)進行超聲裂解，再利用抗原抗體特異性反應將與目的蛋白相結(jié)合的DNA片段沉淀下來，再進行解交聯(lián)釋放結(jié)合蛋白的DNA片段，最后對獲得的DNA片段進行測序分析。這些繁瑣的步驟中會大量損失樣本和信息，因此傳統(tǒng)的ChIP-Seq方法具有需要大量細胞、重復性差、低信號、高背景等缺點。
2017年，Henikoff博士及其實驗室的研究人員在eLife雜志上發(fā)表了一種稱為CUT&RUN的新方法。CUT&RUN（Cleavage Under Targets and Release Using），即核酸酶靶向切割及釋放技術(shù)。CUT&RUN技術(shù)的出現(xiàn)，克服了傳統(tǒng)ChIP-seq方法的缺陷，可以在細胞天然染色質(zhì)環(huán)境下進行蛋白-DNA互作的研究。
Epigentek公司的熱銷產(chǎn)品
產(chǎn)品名稱 | 貨號 | 規(guī)格 |
MethylFlash Methylated DNA 5-mC Quantification Kit (Colorimetric) | P-1034-96 | 96 Assays |
EpiQuik Total Histone Extraction Kit | OP-0006-100 | 100 Extractions |
EpiQuik Nuclear Extraction Kit | OP-0002-1 | 100 Assays |
BisulFlash DNA Modification Kit | P-1026-050 | 50 Reactions |
EpiQuik DNA Methyltransferase (DNMT) Activity/Inhibition Assay Kit | P-3001-1 | 48 Assays |
MethylFlash Methylated DNA 5-mC Quantification Kit (Colorimetric) | P-1034-48 | 48 Assays |
EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric) | P-9005-96 | 96 Reactions |
EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric) | P-9005-48 | 48 Reactions |
MethylFlash Hydroxymethylated DNA 5-hmC Quantification Kit (Colorimetric) | P-1036-96 | 96 Assays |
EpiQuik Chromatin Immunoprecipitation (ChIP) Kit | P-2002-1 | 24 Reactions |
Methylamp DNA Modification Kit | P-1001-2 | 80 Reactions |
MethylFlash Global DNA Methylation (5-mC) ELISA Easy Kit (Colorimetric) | P-1030-96 | 96 reactions |
MethylFlash Methylated DNA Quantification Kit (Fluorometric) | P-1035-96 | 96 Assays |
EpiQuik Plant ChIP Kit | P-2014-48 | 48 Reactions |
5-Methylcytosine (5-mC) Monoclonal Antibody [33D3] | A-1014-050 | 50 ug |
Methylamp Global DNA Methylation Quantification Ultra Kit | P-1014B-48 | 48 Assays |
Methylamp DNA Modification Kit | P-1001-1 | 40 Reactions |
Methylamp Global DNA Methylation Quantification Ultra Kit | P-1014B-96 | 96 Assays |
EpiQuik DNMT Activity/Inhibition Assay Ultra Kit (Colorimetric) | P-3009-48 | 48 Assays |
EpiQuik Plant ChIP Kit | P-2014-24 | 24 Reactions |
MethylFlash Hydroxymethylated DNA 5-hmC Quantification Kit (Colorimetric) | P-1036-48 | 48 Assays |
Methylamp Methylated DNA Capture (MeDIP) Kit | P-1015-48 | 48 Reactions |
EpiQuik 8-OHdG DNA Damage Quantification Direct Kit (Colorimetric) | P-6003-96 | 96 Assays |
Epigenase HDAC Activity/Inhibition Direct Assay Kit (Colorimetric) | P-4034-96 | 96 Assays |
EpiQuik Tissue Chromatin Immunoprecipitation (ChIP) Kit | P-2003-1 | 24 Reactions |
MethylFlash Hydroxymethylated DNA Quantification Kit (Fluorometric) | P-1037-96 | 96 Assays |
MethylFlash Methylated DNA Quantification Kit (Fluorometric) | P-1035-48 | 48 Assays |
EpiQuik Total Histone H3 Acetylation Detection Fast Kit (Colorimetric) | P-4030-96 | 96 Assays |
Methylamp Whole Cell Bisulfite Modification Kit | P-1016-80 | 80 Samples |
EpiQuik Total Histone H4 Acetylation Detection Fast Kit (Colorimetric) | P-4032-96 | 96 Assays |
EpiQuik DNA Methyltransferase (DNMT) Activity/Inhibition Assay Kit | P-3001-2 | 96 Assays |
EpiQuik Global Histone H3 Acetylation Assay Kit | P-4008-96 | 96 Assays |
Histone H3K9me3 (H3K9 Trimethyl) Polyclonal Antibody | A-4036-025 | 25 ul |
EpiQuik Chromatin Immunoprecipitation (ChIP) Kit | P-2002-2 | 48 Reactions |
EpiQuik HDAC Activity/Inhibition Assay Kit (Colorimetric) | P-4002-96 | 96 Assays |
EpiQuik MeDIP Ultra Kit | P-1052-48 | 48 Reactions |
5-Methylcytosine (5-mC) Monoclonal Antibody [33D3] | A-1014-010 | 10 ug |
EpiQuik DNMT Activity/Inhibition Assay Ultra Kit (Colorimetric) | P-3009-96 | 96 Assays |
EpiQuik Hydroxymethylated DNA Immunoprecipitation (hMeDIP) Kit | P-1038-24 | 24 Reactions |
EpiQuik Global Histone H4 Acetylation Assay Kit | P-4009-96 | 96 Assays |
EpiQuik One-Step DNA Hydrolysis Kit | P-1023-96 | 96 Samples |
EpiQuik Global Histone H3 Acetylation Assay Kit | P-4008-48 | 48 Assays |
EpiQuik Global Histone H4 Acetylation Assay Kit | P-4009-48 | 48 Assays |
5-Methylcytosine (5-mC) Monoclonal Antibody [33D3] | A-1014-100 | 100 ug |
Histone H3K9me2 (H3K9 Dimethyl) Polyclonal Antibody | A-4035-050 | 50 ul |
Histone H3K27me3 (H3K27 Trimethyl) Polyclonal Antibody | A-4039-025 | 25 ul |
EpiQuik Tissue Acetyl-Histone H3 ChIP Kit | P-2012-24 | 24 Reactions |
EpiQuik Dnmt1 Assay Kit | P-3011-2 | 48 Assays |
EpiQuik HAT Activity/Inhibition Assay Kit | P-4003-96 | 96 Assays |
EpiQuik Tissue Chromatin Immunoprecipitation (ChIP) Kit | P-2003-2 | 48 Reactions |
