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Nearly two decades ago, Gibco™ CTS™ Dynabeads™ CD3/CD28technology was used in the first pioneering, clinically approvedCAR T cell therapy [1]. The antibody-coated magnetic beadswere crucial in the manufacturing process to achieve one-stepcell isolation and activation, and enabled clinical-scale doseproduction within 2 to 3 weeks. Since then, the technology hasbecome well established in the industry and has been used inover 200 clinical trials to provide critically needed treatment forpatients. Despite these successes, challenges remain to furtherimprove the reliability, consistency, and longevity of treatmentoutcomes. As well, there is still a need to accelerate and expandtreatment delivery to patients [2].Research and clinical outcomes have established that deliveringa higher-quality pool of early T cell phenotypes is key toimproving the reliability and longevity of therapeutic outcomes [3].To aid in the production of the desired phenotypes, the Gibco™CTS™ Detachable Dynabeads™ CD3/CD28 (active-release beads)were developed. The active-release beads build on the one-stepisolation and activation feature of CTS Dynabeads CD3/CD28(passive-release beads) by adding the flexibility of an activerelease mechanism. This enables termination of activationsignaling by releasing the beads at any time after activation usingthe Gibco™ CTS™ Detachable Dynabeads™ Release Buffer. Thisfeature was designed to help preserve an early T cell phenotypeand shorten the T cell manufacturing process to a few days.Additionally, the active-release beads and release buffer arecompatible for use in the scalable, closed, and automatedGibco™ CTS™ DynaCellect™ Magnetic Separation System.CTS Detachable Dynabeads CD3/CD28 and the CTS DetachableDynabeads Release Buffer were evaluated in a comparativebench-scale study to assess the performance of T cell activationas well as cell expansion post-activation, CD4+:CD8+ ratios, andearly phenotype, relative to the passive-release beads. Anotherstudy was conducted with the active-release beads in the CTSDynaCellect Magnetic Separation System to evaluate T cell purity,isolation efficiency, and activation with bead release on differentdays post-activation.