flexcell細(xì)胞應(yīng)力加載培養(yǎng)2019新文獻(xiàn)

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美國Flexcell公司，成立于1987年，該公司專注于細(xì)胞力學(xué)培養(yǎng)產(chǎn)品的設(shè)計(jì)和制造。以提供*的體外細(xì)胞拉應(yīng)力、壓應(yīng)力和流體剪切應(yīng)力加載刺激系統(tǒng)以及配套的培養(yǎng)板、硅膠膜載片等耗材*。

Flexcell細(xì)胞組織力學(xué)培養(yǎng)系統(tǒng)不僅能對各種2D、3D細(xì)胞組織提供拉應(yīng)力、壓應(yīng)力、切應(yīng)力刺激加載,而且還可以提供拉應(yīng)力和切應(yīng)力混合力同時(shí)加載;不僅能對細(xì)胞組織進(jìn)行機(jī)械力加載刺激,而且還能進(jìn)行三維培養(yǎng)、人工生物組織構(gòu)建、動(dòng)力模擬;不僅能單軸向牽張拉伸,而且還可以雙軸向牽張拉伸;不僅可以根據(jù)實(shí)驗(yàn)需要調(diào)節(jié)受力大小,而且還可以模擬不同受力時(shí)間。

Flexcell*的StageFlexer拉應(yīng)力顯微設(shè)備、StagePresser壓應(yīng)力顯微設(shè)備、Flex Flow切應(yīng)力顯微設(shè)備，可在加力培養(yǎng)的同時(shí)實(shí)時(shí)觀察研究細(xì)胞組織在力作用下的反應(yīng)變化；*的flexstop隔離閥能使同一塊培養(yǎng)板里的細(xì)胞組織一部分受力，一部分不受力，方便進(jìn)行對比實(shí)驗(yàn)

這些系統(tǒng)智能、精準(zhǔn)誘導(dǎo)來自各種細(xì)胞、組織在拉應(yīng)力、壓應(yīng)力和流體切應(yīng)力作用下發(fā)生的生化生理變化，專業(yè)、細(xì)膩的闡釋了體外細(xì)胞、組織機(jī)械力刺激加載、力學(xué)信號感受和響應(yīng)機(jī)制。對研究細(xì)胞的形態(tài)結(jié)構(gòu)及功能，細(xì)胞的生長、發(fā)育、成熟、增殖、衰老、凋亡、死亡及癌變以及通路表達(dá)，細(xì)胞信號傳導(dǎo)及基因表達(dá)的調(diào)控，細(xì)胞的分化及其調(diào)控機(jī)理具有重要意義。

細(xì)胞組織應(yīng)力背景與作用
生命活動(dòng)中無論是心臟的博動(dòng)、動(dòng)脈的收縮和舒張、腸道的蠕動(dòng)，骨生長正畸，肌肉生長正畸，血管蠕動(dòng)，肢體運(yùn)動(dòng)，器官活動(dòng)，還是胸肺的呼吸都不斷地對參與其中的細(xì)胞施加動(dòng)態(tài)的應(yīng)力（拉應(yīng)力、壓應(yīng)力、切應(yīng)力）作用。因此正確理解細(xì)胞對外應(yīng)力刺激行為對骨肉正畸、肌肉收縮、創(chuàng)傷修復(fù)、腫瘤轉(zhuǎn)移、器官組織康復(fù)等許多重要生物醫(yī)學(xué)領(lǐng)域都有十分重要的意義

應(yīng)力信號協(xié)同生物化學(xué)信號是生物自適應(yīng)結(jié)構(gòu)自我設(shè)計(jì)和調(diào)控長成的設(shè)計(jì)和調(diào)控者，細(xì)胞核是細(xì)胞代謝活動(dòng)的控制中心，指揮它的活動(dòng)除了遺傳密碼外主要是外部刺激傳來的信號。細(xì)胞處于組織的應(yīng)力環(huán)境中，應(yīng)力刺激細(xì)胞膜并通過微絲和微管傳遞到細(xì)胞核，應(yīng)力信號在傳遞過程中引起一系列生化反應(yīng)。研究成果已證明應(yīng)力信號與化學(xué)信號在決定細(xì)胞活動(dòng)中具有同等重要性，應(yīng)力信號在調(diào)控細(xì)胞的分化、生長和凋亡中起著主導(dǎo)作用。應(yīng)力刺激按作用方向分為張應(yīng)力、壓應(yīng)力和切應(yīng)力（血流對管壁）等，按時(shí)間分為定常和脈動(dòng)應(yīng)力。 
研究確認(rèn)應(yīng)力是調(diào)控功能細(xì)胞的決定性因素 
應(yīng)力仿真加載模擬膜型是細(xì)胞力學(xué)研究面臨的shou要問題
由于生物體內(nèi)器官和組織結(jié)構(gòu)極其復(fù)雜，生物個(gè)體也存在較大差異，致使在體細(xì)胞的力學(xué)環(huán)境復(fù)雜多樣，從而增加在體細(xì)胞力學(xué)行為研究的難度。由于生物體內(nèi)的細(xì)胞、細(xì)胞膜極小，宏觀力學(xué)加載方法和實(shí)驗(yàn)技術(shù)無法直接使用，因此，尋找合適細(xì)胞力學(xué)加載方法和能膜擬生命體內(nèi)細(xì)胞組織生長生物力環(huán)境的細(xì)胞組織體外機(jī)械力加載裝置，實(shí)現(xiàn)體外分離和建立合適的加載膜型是細(xì)胞力學(xué)研究面臨的要問題。美國Fexcell®研制的體外細(xì)胞組織拉應(yīng)力、壓應(yīng)力、和流體剪切力加載仿真模擬模型系統(tǒng)智能、精準(zhǔn)誘導(dǎo)來自各種細(xì)胞、組織在拉力、壓力和流體切應(yīng)力等體外機(jī)械力刺激作用下發(fā)生的生化生理變化，專業(yè)、細(xì)膩的闡釋了體外細(xì)胞、組織機(jī)械力刺激加載、力學(xué)信號感受和響應(yīng)機(jī)制。國內(nèi)外有近3000篇成功應(yīng)用文獻(xiàn)案例，是細(xì)胞組織力學(xué)研究者的shou選。 
Flexcell總授權(quán)代理
世聯(lián)博研北京科技有限公司是Flexcell細(xì)胞力學(xué)設(shè)備與耗材在中國大陸、香港、澳門、馬來西亞、新加波區(qū)域總授權(quán)代理商， 為廣大科研用戶提供flexcell全系列產(chǎn)品。