INNOTERE Paste-CPC旨在填補(bǔ)創(chuàng)傷，重建或矯正干預(yù)后未感染的骨缺損。它是世界上di一種可注射的磷酸鈣基骨水泥糊劑，可作為即用型植入材料提供。一項(xiàng)新穎的，受專li保護(hù)的技術(shù)取代了對詳盡，耗時(shí)的術(shù)中骨替代水泥的制備，混合和轉(zhuǎn)移的需求。INNOTERE Paste-CPC可以直接使用，可以直接從注射器中使用，也可以通過使用套管將其粘貼到骨骼中。由于INNOTERE Paste-CPC僅在與水性液體接觸后才凝固，而不是在注射器中凝固，因此外科醫(yī)生在施工過程中沒有時(shí)間限制。自2015年初以來，INNOTERE Paste-CPC即可在歐盟用于臨床應(yīng)用。

• Implant Augmentation for Trochanteric Fractures with an Innovative, Ready to Use Calcium-Phosphate-Cement. Fuchs A, Langenmair E, Hirschmueller A, Suedkamp NP, Konstantinidis L Journal of Orthopaedics and Bone Research 2019

• Incorporation of silicon into strontium modified calcium phosphate bone cements promotes osteoclastogenesis of human peripheral mononuclear blood cells. Wagner AS, Schumacher M, Rohnke M, Glenske K, Gelinsky M, Arnhold S, Mazurek S, Wenisch S Biomedical Materials 2019

• Strontium-modified premixed calcium phosphate cements for the therapy of osteoporotic bone defects. Lode A, Heiss C, Knapp G, Thomas J, Nies B, Gelinsky M, Schumacher M  Acta Biomaterialia 2018

• Ready-to-use injectable calcium phosphate bone cement paste as drug carrier. Vorndran E, Geffers M, Ewald A, Lemm M, Nies B, Gbureck U Acta Biomater 2013

• Properties of injectable ready-to-use calcium phosphate cement based on water-immiscible liquid. Heinemann S, Rössler S, Lemm M, Ruhnow M, Nies B Acta Biomater 2013 

INNOTERE 3D支架是一種合成的，多孔的，生物相容的且具有生物可吸收性的骨替代材料，用于填充或重建不承重的骨缺損或用于填充骨缺損，這些骨缺損已通過適當(dāng)?shù)姆绞竭M(jìn)行了充分穩(wěn)定。與傳統(tǒng)的預(yù)制骨替代品相比，INNOTERE 3D支架的特點(diǎn)是：

• 互連孔隙

• 使用全合成原材料的骨狀礦物相

• 可通過骨骼重塑過程吸收

INNOTERE 3D支架的創(chuàng)新功能來自使用INNOTERE創(chuàng)新的磷酸鈣骨水泥漿的新3D打印技術(shù)。該方法允許精確地調(diào)節(jié)所得支架的互連孔系統(tǒng)的孔隙率。所用的磷酸鈣糊劑在印刷過程之后通過特定的固化程序進(jìn)行固化，無需任何燒結(jié)步驟。這樣可以避免晶體生長，并導(dǎo)致支架主要由天然骨骼的礦相微晶羥基磷灰石組成。

INNOTERE 3D支架的特定應(yīng)用領(lǐng)域是：

• 干defect端骨折，例如脛骨，radius骨和肱骨骨折

• 良性腫瘤和囊腫切除后的骨缺損

• 口腔頜面外科的骨缺損

• 填充脊髓籠

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• 3D Plotted Biphasic Bone Scaffolds for Growth Factor Delivery: Biological Characterization In Vitro and In Vivo. Ahlfeld T, Schuster FP, Foerster Y, Quade M, Akkineni AR, Rentsch C, Rammelt s, Lode A, Gelinsky M Advance Healthcare Materials 2019

• Bioprinting of mineralized constructs utilizing multichannel plotting of a self-setting calcium phosphate cement and a cell-laden bioink. Ahlfeld T, Doberenz F, Kilian D, Vater C, Korn P, Lauer G, Lode A, Gelinsky M Biofabrication 2018

• A Methylcellulose Hydrogel as Support for 3D Plotting of Complex Shaped Calcium Phosphate Scaffolds. Ahlfeld T, Koehler T, Czichy C, Lode A, Gelinsky M Gels 2018

• Strontium(II) and Mechanical Loading Additively Augment Bone Formation in Calcium Phosphate Scaffolds. Reitmaier S, Kovtun A, Schuelke J,  Kanter B, Lemm M, Hoess A, Heinemann S, Nies B, Ignatius A Journal of Orthopaedic Research 2017

• In situ functionalization of scaffolds during extrusion-based 3D plotting using a piezoelectric nanoliter pipette. Giron S, Lode A, Gelinsky M  Journal of 3D Printing in Medicine 2016

• 3D plotting of growth factor loaded calcium phosphate cement scaffolds. Akkineni AR, Luo Y, Schumacher M, Nies B, Lode A, Gelinsky M Acta Biomaterialia 2015

• Medium-Term Funkction of a 3D Printed TCP/HA Structure as a New Osteoinductive Scaffold for Vertical Bone Augmentation: A Simulation by BMP-2 Activation. Moussa M, Carrel JP, Scherrer S, Cattani-Lorente M, Wiskott A, Durual S Materials 2015

• A 3D printed TCP/HA structure as a new osteoconductive scaffold for vertical bone augmentation. Carrel JP, Wiskott A, Moussa M, Rieder P, Scherrer S, Durual S Clinical Oral Implants Research 2014

• Fabrication of porous scaffolds by three-dimensional plotting of a pasty calcium phosphate bone cement under mild conditions. Lode A, Meissner K, Luo Y, Sonntag F, Glorius S, Nies B, Vater C, Despang F, Hanke T, Gelinsky M Journal of Tissue Engineering and Regenerative Medicine 2014 

• Well-ordered biphasic calcium phosphate–alginate scaffolds fabricated by multi-channel 3D plotting under mild conditions. Lou Y, Lode A, Sonntag F, Nies B, Gelinsky M Journal of Materials Chemistry B 2013

 磷酸三鈣（TCP）是骨骼和牙齒礦物質(zhì)相的一部分。它構(gòu)成了臨床上用作合成骨移植替代品的大多數(shù)無機(jī)骨水泥的基礎(chǔ)。通過標(biāo)準(zhǔn)化的燒結(jié)工藝，INNOTERE可以為您提供相純度≥98％且批次間可重復(fù)性的α-TCP粉末或β-TCP粉末。

可根據(jù)要求提供無菌粉末，確定粒徑的微粉，特殊包裝以及用于制造醫(yī)療器械的原材料。

• Calcium Phosphate Spacers for the Local Delivery of Sitafloxacin and Rifampin to Treat Orthopedic Infections: Efficacy and Proof of Concept in a Mouse Model of Single-Stage Revision of Device-Associated Osteomyeliti. Trombetta RP, Ninomiya MJ, El-Atawneh IM, Knapp EK, de Mesy Bently KL, Dunman PM, Schwarz EM, Kates SL, Awad HA  Pharmaceutics 2019

• Three dimensional printed calcium phosphate and poly(caprolactone) composites with improved mechanical properties and preserved microstructure. Vella JB, Trombetta RP, Hoffman MD, Inzana J, Awad H, Benoit DSW Journal of Biomedical Materials Research Part A 2018

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