| 廣州測(cè)迪生物科技有限公司
主營產(chǎn)品： 美國kernel試劑盒,德國拜發(fā)試劑盒,瑞士Prionics試劑盒,荷蘭賽迪試劑盒 |
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| 廣州測(cè)迪生物科技有限公司
主營產(chǎn)品： 美國kernel試劑盒,德國拜發(fā)試劑盒,瑞士Prionics試劑盒,荷蘭賽迪試劑盒 |
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更新時(shí)間：2017-05-28 13:42:24瀏覽次數(shù)：1336
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荷蘭賽迪ceditest/瑞士prionics公司
華南地區(qū)總代 廣州測(cè)迪生物科技有限公司 楊
PrioCHECK® FMD IPC 3ABC
介紹：很多國家通過接種疫苗和監(jiān)控檢測(cè)來控制口蹄疫疫情，通過檢測(cè)來區(qū)分野毒感染和疫苗接種動(dòng)物，能否獲得高純度疫苗是其中至關(guān)重要的步驟。我們Prionics公司榮幸的推出PrioCHECK® FMD IPC 3ABC檢測(cè)套裝，能讓疫苗廠家在生產(chǎn)過程中監(jiān)測(cè)其疫苗的純度。
當(dāng)前，口蹄疫疫苗是通過對(duì)牛攻毒實(shí)驗(yàn)來檢測(cè)其純度，該方法耗時(shí)耗力而且相當(dāng)昂貴。因此對(duì)于疫苗生產(chǎn)廠家，尋找一種快速的體外診斷方法來控制疫苗生產(chǎn)過程中口蹄疫非結(jié)構(gòu)蛋白對(duì)疫苗抗原的污染，迫在眉睫。我們推出的PrioCHECK® FMD IPC 3ABC，就是一種檢測(cè)口蹄疫疫苗純度的高效廉價(jià)方法。該方法能在疫苗生產(chǎn)過程中免疫定量測(cè)定疫苗抗原中非結(jié)構(gòu)蛋白的含量。能檢測(cè)低至2-4ng的3abc蛋白。
Foot and Mouth Disease (FMD) poses a serious economic threat to the livestock industry. The spread of the disease is controlled through vaccination and surveillance programs using diagnostic tests to detect antibodies against the non-structural (NS) proteins (such as 3ABC or 3D) of the FMD virus. These dedicated NS tests, also known as DIVA (discriminate infected from vaccinated animals) tests, help to eradicate the disease faster and support the preferred ”vaccination-to-live” policy. In order to enable the discrimination between vaccinated and infected animals with NS tests, it is of primary importance that FMD vaccines do not contain the FMD virus NS proteins. If vaccines contain the virus, a vaccinated animal would be diagnosed as positive in an NS test.
In vitro testing could replace challenge testing in cattle
Currently, FMD vaccines are tested for purity by challenge testing in cattle, an expensive and time-consuming method. Vaccine manufacturers therefore have been in need of a fast in vitro test to control for contamination of vaccine-antigen batches with FMD virus non-structural proteins during the vaccine manufacturing process (i.e. in-process control). The PrioCHECK® FMD IPC 3ABC of Prionics now offers a fast, efficient and cost-effective tool to determine FMDV vaccine purity. The PrioCHECK® FMD IPC 3ABC is an in-process control (IPC) immunoassay for the detection and quantification of the non-structural 3ABC protein in vaccine-antigen batches, regardless of their volume and composition. The test is able to detect as little as 2 - 4 ng of the 3ABC protein. This is well below the amount of protein needed to induce antibodies even after multiple vaccinations.
Reduced production costs
When vaccine producers use the PrioCHECK® FMD IPC 3ABC to check the purity of their vaccine batches during production, fewer batches will have to be rejected. In-process control testing contributes significantly to reducing vaccine production costs. Furthermore, in-process control testing of FMD vaccine batches reduces the need for challenge testing in cattle, an expensive and time-consuming procedure. In addition, the PrioCHECK® FMD IPC 3ABC in vitro assay will make a significant contribution towards the efforts to refine, reduce and replace animals for evaluation of biological products (i.e. the 3Rs concept of Russell and Burch).
With the PrioCHECK® FMD IPC 3ABC test for vaccine control and the PrioCHECK® FMDV NS DIVA test, Prionics provides a complete solution for FMD eradication.
