Rad51 mouse mAb
抗體，也叫免疫球蛋白（Ig），是一種能特異性結合抗原的糖蛋白，而抗原是在易感染動物體內引發(fā)抗體產生的物質。在體內，抗體是由于外源性分子的侵襲而產生的?？贵w以一個或者多個Y字形單體存在，每個Y字形單體由4條多肽鏈組成，包含兩條相同的重鏈和兩條相同的輕鏈。輕鏈和重鏈是根據它們的分子量大小來命名的。Y字形結構的頂端是可變區(qū)，為抗原結合部位。任何一個抗體的輕鏈都可以分為κ或λ型（基于小分子多肽結構上的差異），每一個抗體的重鏈則決定了它的類或型。
產品詳情
This antibody detects endogenous levels of Rad51 and does not cross-react with related proteins.
免疫原詳細信息
Recombinant protein of human Rad51.
相關試劑
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
天津俊達生物科技有限公司，是從事實驗室耗材銷售的現代化生物科技企業(yè)，公司本著“誠信為本，互利共贏"的核心價值觀，秉承“以市場為導向，提供服務"的宗旨為各大院校、科研單位、第三方實驗室檢測機構等提供的產品和服務。目前公司主要經營分子生物學、細胞生物學、免疫學等生物學產品，多種實驗室耗材 歡迎垂詢！
備注：圖片僅供參考。僅供科研，不可用于臨床。
化工儀器網