精品国产亚洲国产亚洲,久热中文在线观看精品视频,成人三级av黄色按摩,亚洲AV无码乱码国产麻豆

您好, 歡迎來到化工儀器網(wǎng)

| 注冊| 產(chǎn)品展廳| 收藏該商鋪

13611715263

products

目錄:MedChemExpress LLC>>信號通路>> Imatinib Mesylate | MedChemExpress

Imatinib Mesylate | MedChemExpress
  • Imatinib Mesylate | MedChemExpress
參考價 550
具體成交價以合同協(xié)議為準(zhǔn)
參考價 550
具體成交價以合同協(xié)議為準(zhǔn)
  • 品牌 MedChemExpress (MCE)
  • 型號
  • 廠商性質(zhì) 生產(chǎn)商
  • 所在地 國外
屬性

$NV_PropertyInfoName.SubString(0,25)

>

更新時間:2023-09-28 14:47:41瀏覽次數(shù):197評價

聯(lián)系我們時請說明是化工儀器網(wǎng)上看到的信息,謝謝!

同類優(yōu)質(zhì)產(chǎn)品

更多產(chǎn)品
CAS 220127-57-1 純度 99.98%
分子量 589.71 分子式 C??H??N?O?S
供貨周期 現(xiàn)貨 規(guī)格 10 mM * 1 mL
貨號 HY-50946 應(yīng)用領(lǐng)域 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥/生物制藥
Imatinib Mesylate (STI571 Mesylate) 是一種酪氨酸激酶抑制劑,可抑制 <b>c-Kit</b>,<b>Bcr-Abl</b> 和 <b>PDGFR</b> (<b>IC<sub>50</sub></b>=100 nM)。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報,我們不為任何個人用途提供產(chǎn)品和服務(wù)。

Imatinib Mesylate

CAS No. : 220127-57-1

MCE 國際站:Imatinib Mesylate

產(chǎn)品活性:Imatinib Mesylate (STI571 Mesylate) 是一種酪氨酸激酶抑制劑,可抑制 c-Kit,Bcr-AblPDGFR (IC50=100 nM)。

研究領(lǐng)域:Protein Tyrosine Kinase/RTK  |  Autophagy

作用靶點:c-Kit  |  Bcr-Abl  |  PDGFR  |  Autophagy

In Vitro: Imatinib (STI571) Mesylate inhibits c-Kit autophosphorylation, activation of MAPK, and activation of Akt without altering total protein levels of c-kit, MAPK, or Akt. The concentration that produces 50% inhibition for these effects is approximately 100 nM. Imatinib (STI571) mesylate is very effective (in vitro IC50 of 25 nM) against the chronic myeloid leukemia-causing kinase Bcr-Abl. Imatinib also efficiently inhibits Kit (in vitro IC50, 410 nM) and PDGFR (in vitro IC50, 380 nM). Imatinib (STI571) mesylate is a multi-target inhibitor of v-Abl, c-Kit and inhibits Bcr/Abl, v-Abl, Tel/Abl, the native PDGFβ receptor, and c-Kit, but it does not inhibit Src family kinases, c-Fms, Flt3, the EGFR or multiple other tyrosine kinases. Imatinib inhibits tyrosine phosphorylation and cell growth of Ba/F3 cells expressing Bcr/Abl, Tel/Abl, Tel/PDGFβR, and Tel/Arg with an IC50 of approximately 0.5 μM in each case, but it has no effect on untransformed Ba/F3 cells growing in IL-3 or on Ba/F3 cells transformed by Tel/JAK2. Imatinib mesylate selectively inhibits the activity of Bcr/Abl, c-Kit and PDGFR kinases. Imatinib mesylate reveals distinct and rapid antileukemic activity in chronic myelogenous leukemia (CML) and Philadelphia-positive (Ph+) acute lymphoblastic leukemia (ALL).

In Vivo: Animals treated with Imatinib Mesylate show a decrease of mean body weight throughout the whole study. Body weight loss is noticeable in mice from groups that receive chemotherapy and the vitamin D analog combined treatment. The body weight decrease of mice treat with both combined Imatinib mesylate and PRI-2191 is the highest (15%) on Day 22 of the experiment, but after that day, mice start to recover. In a rat Ischemia/reperfusion injury (IRI) model, Imatinib mesylate attenuates lung injury by an antipermeability and antiinflammatory effect. The delivery and function of Imatinib mesylate in the lung is also confirmed in this model.

相關(guān)產(chǎn)品:Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Protein Tyrosine Kinase Compound Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  Antiviral Compound Library  |  CNS-Penetrant Compound Library  |  Autophagy Compound Library  |  Drug Repurposing Compound Library  |  Reprogramming Compound Library  |  NMPA-Approved Drug Library  |  Cytoskeleton Compound Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Anti-Alzheimer's Disease Compound Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Targeted Therapy Drug Library   |  Anti-Parkinson's Disease Compound Library  |  Neurodegenerative Disease-related Compound Library  |  Angiogenesis-Related Compound Library  |  Anti-Liver Cancer Compound Library   |  Rare Diseases Drug Library  |  Children’s Drug Library  |  EMA-Approved Drug Library  |  FDA-Approved Anticancer Drug Library  |  Human Metabolite Library  |  Anti-Prostate Cancer Compound Library  |  Anti-Pulmonary Fibrosis Compound Library  |  Off-patent Drug Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Cytokine Inhibitors Library  |  Cell Death Library  |  SNIPER(ABL)-013  |  Sennoside B  |  AT9283  |  Bafetinib  |  Flumatinib mesylate  |  Multi-kinase-IN-2  |  PP58  |  c-Kit-IN-5-1  |  CT52923  |  Olverembatinib  |  Pexidartinib  |  ENMD-2076 Tartrate  |  GNF-2  |  AZD2932  |  Toceranib phosphate  |  BCR-ABL-IN-6  |  Ponatinib hydrochloride  |  GNF-5  |  Famitinib malate  |  AC710 Mesylate  |  Hypothemycin  |  Nintedanib  |  Motesanib Diphosphate  |  Vamotinib  |  Tandutinib  |  Telatinib mesylate  |  CT-721  |  Tyrphostin AG1433  |  Masitinib  |  Nintedanib-13C,d3

熱門產(chǎn)品線:重組蛋白  |  化合物庫  |  天然產(chǎn)物  |  熒光染料  |  PROTAC  |  同位素標(biāo)記物  |  寡核苷酸  |  抗體  |  點擊化學(xué)

Trending products:Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

類藥多樣性化合物庫
顧客使用MCE產(chǎn)品發(fā)表的科研文獻
一站式藥篩新體驗
MCE 您身邊的生物活性分子大師 | 抑制劑、激動劑、化合物庫
重組蛋白 | 高純度、高穩(wěn)定性
磁珠

會員登錄

請輸入賬號

請輸入密碼

=

請輸驗證碼

收藏該商鋪

標(biāo)簽:
保存成功

(空格分隔,最多3個,單個標(biāo)簽最多10個字符)

常用:

提示

您的留言已提交成功!我們將在第一時間回復(fù)您~
在線留言

會員登錄

請輸入賬號

請輸入密碼

=

請輸驗證碼

收藏該商鋪

該信息已收藏!
標(biāo)簽:
保存成功

(空格分隔,最多3個,單個標(biāo)簽最多10個字符)

常用:
熱線電話 在線詢價
日韩 欧美 一区 二区三区| 欧美va精品亚洲va精品| 国产中文字幕在线一区二区三区| 亚洲av午夜一区二区| 大鸡巴插我在线观看| 美国大鸡巴操逼视频| 欧美综合区自拍亚洲综合| 欧美亚洲熟妇视频在线观看| 亚洲美女后入在线播放| 日韩午夜精品中文字幕| 日韩激情精品久久久一区二区| 日本 日韩 欧美| 精品精品视频国产| 国产精品一区二区在线观看91| 国产在线麻豆精品| 大鸡巴操饿罗斯女人| 日韩亚洲AV无码一区二区不卡| 捆绑调教白浆一区二区三区| 91偷自产一区二区三区蜜臀| 欧美日韩综合在线一区| 白色紧身裤无码系列在线| 又色又爽又黄的吃奶Av| 亚洲午夜av一区二区三区| 日韩免费一级a毛片在线播放一级| 国产午夜精品美女视频露脸| 黑丝美女被操哭边操边尿| 中文字幕亚洲精品女同一页| 激烈18禁高潮视频免费| 日韩午夜经典福利| 西西大尺度无码免费视频| 天美传媒精品1区2区3区| 国产成人亚洲欧美久久| 亚洲精品精品精国产| 美女人的逼免费观看| 92婷婷伊人久久精品一区二区| 无码爆一二三区免费视频| 美女主播被操流水| 国产污污污在线观看视频| 精品麻豆亚洲欧美| 精品精品国产一区二区性色av| 国产日女人视频在线观看|