目錄:MedChemExpress LLC>>信號(hào)通路>> AZD0156 | MedChemExpress
| 參考價(jià) | ￥ 309 |
| 參考價(jià) | ￥ 309 |
更新時(shí)間：2023-09-28 14:55:15瀏覽次數(shù)：140評(píng)價(jià)
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| CAS | 1821428-35-6 | 純度 | 99.82% |
|---|---|---|---|
| 分子量 | 461.56 | 分子式 | C??H??N?O? |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 1 mg |
| 貨號(hào) | HY-100016 | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥/生物制藥 |
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CAS No. : 1821428-35-6
MCE 國(guó)際站：AZD0156
產(chǎn)品活性：AZD0156 是一種有效的，選擇性的和口服活性的 ATM 抑制劑，IC50 為 0.58 nM。AZD0156 抑制 ATM 介導(dǎo)的信號(hào)轉(zhuǎn)導(dǎo)，防止 DNA 損傷檢查點(diǎn)激活，破壞 DNA 損傷修復(fù)，并誘導(dǎo)腫瘤細(xì)胞凋亡 (apoptosis)。
研究領(lǐng)域：Cell Cycle/DNA Damage | PI3K/Akt/mTOR | Apoptosis
作用靶點(diǎn)：ATM/ATR | Apoptosis
In Vitro: AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells.
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