目錄:MedChemExpress LLC>>信號通路>> Gartisertib | MedChemExpress
| CAS | 1613191-99-3 | 純度 | 99.76% |
|---|---|---|---|
| 分子量 | 541.55 | 分子式 | C??H??F?N?O? |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL |
| 貨號 | HY-136270 | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥/生物制藥 |
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CAS No. : 1613191-99-3
MCE 國際站：Gartisertib
產(chǎn)品活性：Gartisertib (VX-803) 是一種 ATP 競爭性的，具有口服活性的，選擇性的 ATR 抑制劑，Ki<150 pM。Gartisertib 抑制 ATR 驅(qū)動的磷酸化檢查點激酶-1 (Chk1) 磷酸化, IC50值為 8 nM。具有抗腫瘤活性。
研究領(lǐng)域：Cell Cycle/DNA Damage | PI3K/Akt/mTOR
作用靶點：ATM/ATR
In Vivo: In monotherapy efficacy studies Gartisertib shows tumor stasis to regression in tumor models with alternative lengthening of telomeres (ALT). In combination with PARP inhibitors, tumor regression could be observed in triple-negative breast cancer xenograft models.
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