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Vorinostat

CAS No. : 149647-78-9

MCE 國際站：Vorinostat

產品活性：Vorinostat (SAHA) 是一種有效的，可口服的 HDAC1，HDAC2，HDAC3 (Class I)，HDAC6 和 HDAC7 (Class II) 和 Class IV (HDAC11) 的抑制劑，對 HDAC1/3 的 ID₅₀ 值分別為 10 nM 和 20 nM。Vorinostat 可以誘導細胞凋亡 (apoptosis)。Vorinostat 還是一種人類乳頭瘤病毒 (HPV)-18 DNA 擴增的有效抑制劑。

研究領域：Cell Cycle/DNA Damage  |  Epigenetics  |  Autophagy  |  Anti-infection  |  Apoptosis

作用靶點：HDAC  |  Autophagy  |  Mitophagy  |  Filovirus  |  Apoptosis  |  HPV

In Vitro: Vorinostat efficiently suppresses MES-SA cell growth at a low dosage (3 μM) already after 24 hours treatment. HDACs class I (HDAC2 and 3) as well as class II (HDAC7) are preferentially affected by this treatment. Vorinostat significantly increases p21^WAF1 expression and apoptosis in MES-SA cells.
Vorinostat inhibits SK-N-SH and SK-N-Be(2)C with the IC₂₅ values of 1 µM and 0.5 µM, respectively.
Vorinostat is an effective inhibitor of HPV-18 DNA amplification, reduces oncoproteins E6 and E7 activities and triggers apoptosis in HPV-infected, differentiated cells.

In Vivo: Vorinostat (50 mg/kg/day) reduces tumor growth by more than 50% in nude mice injected with 5×10⁶ MES-SA cells.

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