目錄:MedChemExpress LLC>>信號通路>> Etravirine | 依曲韋林 | MedChemExpress (MCE)
| CAS | 269055-15-4 | 純度 | 99.56% |
|---|---|---|---|
| 分子量 | 435.28 | 分子式 | C??H??BrN?O |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL |
| 貨號 | HY-90005 | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥/生物制藥 |
MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個人用途提供產(chǎn)品和服務(wù)。
CAS No. : 269055-15-4
MCE 國際站：Etravirine
產(chǎn)品活性：Etravirine 是一種非核苷逆轉(zhuǎn)錄酶抑制劑 (NNRTI)，具有抗 HIV 的作用。
研究領(lǐng)域：Anti-infection
作用靶點(diǎn)：Reverse Transcriptase | HIV
In Vitro: TMC125 is highly active against wild-type HIV-1 (50% effective concentration [EC50]=1.4 to 4.8 nM) and shows some activity against HIV-2 (EC50=3.5 μM). TMC125 also inhibits a series of HIV-1 group M subtypes and circulating recombinant forms and a group O virus.?TMC125 has activity for 19 viruses with EC50 of < 5 nM.
In Vivo: Etravirine has a high genetic barrier to the development of resistance. In phase IIb trials in treatment-experienced patients, including those infected with virus resistant to NNRTIs and protease inhibitors (PIs), TMC125 is active against HIV resistant to currently available NNRTIs, with a similar tolerability profile to that of the control group.
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