OsteoGen3D灌注生物反應(yīng)器系統(tǒng) OsteoGen生物反應(yīng)器通過圓筒支架灌注接種細胞。應(yīng)用范圍包括細胞功能研究、組織工程構(gòu)建物生長和發(fā)育、藥物和再生醫(yī)學(xué)測試。目前研究人員正在利用這些系統(tǒng)在廣泛的范圍內(nèi)開展研究領(lǐng)域，包括：
?骨髓干細胞表型研究
?骨髓基質(zhì)干細胞礦物質(zhì)沉積
OsteoGen提供了一個生理支持系統(tǒng)，改善了3D環(huán)境中的細胞生長和代謝條件。系統(tǒng)通過反饋控制再現(xiàn)了生理刺激參數(shù)。

OsteoGen3D灌注生物反應(yīng)器系統(tǒng)（體外三維骨構(gòu)造體接種細胞培養(yǎng)基灌注培養(yǎng)系統(tǒng)）

 OsteoGen生物反應(yīng)器通過圓筒支架灌注接種細胞。應(yīng)用范圍包括細胞功能研究、組織工程構(gòu)建物生長和發(fā)育、藥物和再生醫(yī)學(xué)測試。目前研究人員正在利用這些系統(tǒng)在廣泛的范圍內(nèi)開展研究領(lǐng)域，包括：

• 骨髓干細胞表型研究
• 骨髓基質(zhì)干細胞礦物質(zhì)沉積

 OsteoGen提供了一個生理支持系統(tǒng)，改善了3D環(huán)境中的細胞生長和代謝條件。系統(tǒng)通過反饋控制再現(xiàn)了生理刺激參數(shù)。靈活的硬件和計算機控制系統(tǒng)允許各種各樣的自動化實驗步驟，具有不同程度的復(fù)雜性（壓力幅度和頻率），并可以容納10 mm長度的支架。OsteoGen系統(tǒng)可容納多達12個樣品，樣品之間相互獨立，樣品同時經(jīng)受灌注循環(huán)。灌注泵可以提供低至0.06 mL/min的流量。

 應(yīng)用領(lǐng)域：礦化研究和骨組織工程。

OsteoGen: Perfusion Bioreactor Systems

BISS's OsteoGen bioreactors impart perfusion through cell seeded cylindrical scaffolds. Applications include investigating cell function, modulating the growth and development of engineered tissues, or acting as a test bed for drug and regenerative medicine technologies. Researchers are currently utilizing these systems in a wide range of research areas including:

• Bone stem cell phenotype research
• Mineral deposition of marrowstromal cells

1O OsteoGen

The 1O system has been designed as a single sample bioreactor system that is able to support a wide range of  cell and tissue growth experiments.  This chamber can accommodate a single sample with a maximum size of 10 mm diameter x 10 mm thick. Optional features such as: transducers, non-contact micrometers, pressure sensors, etc., and/or modules to customize the instrument to specific needs can be added to accommodate the research application.

12O OsteoGen

The 12O system has been designed as a single sample multi-chamber bioreactor system that is able to support a wide range of cell and tissue growth experiments via user defined stimulation protocols. This chamber can accommodate a single sample with a maximum size of 10 mm diameter x 10 mm thick. A custom manifold integrates up to 12 chambers with individual flow loops. Optional features such as; transducers, non-contact micrometers, pressure sensors, etc., and/or modules to customize the instrument to specific needs can be added to accommodate the research application.

 

BONE

Key: S=Standard, A=Available, - = not available

CHAMBERS	1O	12O
Individual growth chamber	S	S
12 parallel growth chambers	-	A
Max construct size: 6 mm diameter by 10 mm long	S	S

 

STIMULATION
Pulsatile fluid flow stimulator	A	A

 

CONTROLS
Controller software, computer, and monitor	-	-
Power supplies and cabling	-	-
Mean flow control	A	A
Dynamic flow control	-	-

 

TISSUE MONITORING
Non-contact flow sensors	A	A
Catheter pressure transducers	A	A

 

ACCESSORIES
Media reservoir	S	S
Incubator	A	A

 

BENEFITS
All-autoclavable components	S	S
Excellent sample access	S	S
Medium change without opening chamber via luer fittings	S	S
Increased sterility with fast and clean sample change and access	S	S
Lightweight design for easy handling	S	S
Easily cleaned surface finishes	S	S
Compact design for fit in standard incubators	S	S
100% satisfaction guaranteed warranty	S	S